Research Projects
  1. National Natural Science Foundation of China: The mechanism of control cell function by Micropattern with triple shape memony polymer. Funds:¥820,000 RMB, Duration:2014.01-2017.12.
  2. The specialized research fund for the doctoral program of higher education project (Ph.D. class) research of hydrogen bonding basedshape memory poiymer surface microstructure. Funds:¥120,000 RMB, Duration:2013.01-2015.12.
  3. National Natural Science Foundation of China: Preparation and performance investigation of biodegradable and shape-memory polymer drug carrier. Funds: ¥320,000 RMB,Duration: 2008.1-2010.12.
  4. National Natural Science Foundation of China: Biodegradable polymer temperature-responsive and magnetic nanomicelles . Funds: ¥370,000 RMB, Duration: 2010.1-2012.12.
  5. Surface project of National Natural Science Foundation of China: Morphology regulation and anti-tumor properties of Ether-anhydride copolymer micelles. Funds: ¥600,000 RMB, Duration: 2012.1-2015.12.
  6. As the academic key personnel to participate in the sub-project of National Basic Research Program: Immobilization and controlled release of growth factor in the high activity of micro-nano structure materials. Funds: ¥1350,000 RMB, Duration: 2012.1-2016.12.
  7. New Century Excellent Talents Fund of the Ministry of Education: Controlled release system of biological active macromolecules of protein and peptide. Funds: ¥500,000 RMB, Duration: 2008.1-2010.12.
  8. Outstanding Youth Science and Technology Fund of Sichuan Province: Biodegradable shape memory polymers with controlled drug release properties. Funds: ¥120,000 RMB, Duration: 2008.1-2010.12.
  9. "Young Star" project of the Southwest Jiaotong University. Funds: ¥300,000 RMB, Duration: 2009.9-2012.9.

Research interests

   My research interests mainly include the synthesis and characterization of biodegradable polymers such as PLA, PLA-PEG, PCL-PEG and poly(ether-anhydrides), and their applications in drug delivery, tissue engineering and shape memory polymer composites.

(1) Drug delivery

For cancer therapy, optimization of the carrier features is necessary to effectively deliver the targeting agents to tumor site. We fabricated the biodegradable poly(ether-anhydrides) micelles with filamentous, rod-like and spherical shapes by using a solvent evaporation method. The results of in vivo antitumor activity demonstrate that the filamentous DOX-loaded micelles possess the highest safety to body and the best therapeutic effect to artificial solid tumor. (Pharm. Res., 2010; Advanced Healthcare Materials, 2012)

(2) Shape memory polymer composites

 Shape memory polymers (SMPs), as an emerging class of active materials, have been drawing more and more attention due to their potential applications in medicine.Among these applications, the SMPs as intelligent implants were extensively investigated to replace shape-memory alloys. Remotely actuated shape memory effect of the c-PCL/Fe3O4 nanocomposite can be achieved, triggered by an alternative magnetic field. (Nanotechnology,2009. J.Phys.Chem.C, 2009. Acta Biomateria,2012.)
   Biodegradable polymer stent with shape memory effect is expected to be developed in the treatment of esophageal stenosis, most likely due to traditional stents having such shortages as considerable rigidity and nondegradation. The primary animal experiment in vivo has revealed that the implanted deformed biodegradable polymer stent could be triggered by body temperature and expectedly returned to a nearly-round shape to support esophageal wall. (J.Mater.Sci.-M,2102)

(3) Tissue engineering

   

   

Regulating cellular activities temporally and spatially is particularly essential for regenerating tissues of normal architecture and biological function. The electrospinning process was utilized successfully to fabricate the random oriented (R1) and aligned (A1) electrically conductive nanofibers of biodegradable poly-DL-lactide (PLA) in which multiwalled carbon nanotubes (MWCNTs) were embedded. ?These conductive nanofiber meshes offered a unique system to study the synergistic effect of topographic cues and electrical stimulation on osteoblasts outgrowth as a way of exploring their potential application in bone tissue engineering.(Biomaterials, 2011)

 

 

Copyright © 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心