Team

Postdoctor: Xian Liu.
PhD Student: Hongmei Chen, Lin Wang, Long Li, Xing Guo, Guang Yang, Huili Sun, Tao Gong, Zhaomin Tang, Yi Wang.
Master Student: Zhaomin Tang, Chunli Shi, Shan Ding, Xifeng Yang, Ye Liu, Jie Wang, Kun Zhao, Qianqian Qu, Dan Li, Ying Li, Shubin Di, Wen xi Wang, Guangliang Zhou, Yi Wang, Lei Zhang.
Alumnus: Xiaotong Zhen(Doc.), Chao Luo, Yangbo Zhou, Tao Chen, Wenbing Li, Jinrong Li, Zhao Zhang, Jing Sun, Qiuxiang Su, Hongsen Peng, Lin Sun, Xiongjun Yu, Tao Guo, Yu Xiao, Weijia Wang, Aijun Zhao, Chi Huang, Qi Zhou, Shijun Shao.

 

Research interests

1. Research of new targeted and controlled release of drug.

a. pH-triggered intracellular release from actively targeting polymer micelles
FA bared onto the surface of the nanocarriers facilitates the endocytosis by the FR over-expressing tumor cells. Once the polymeric prodrugs are internalized by the tumor cells and included into the endo/lysosomes, the hydrazone linkages are ruptured due to the acidic microenvironment and DOX is released from polymer. It is evidenced that the combination of the FR mediated targeting and the pH-triggered release of payloads can greatly improve the therapeutic efficiency and decrease the drug toxicity

Figure. Ex vivo DOX fluorescence images showing the DOX bio-distribution (a) and excised 4T1 solid tumors from different treatment groups(b).
*Xing Guo, Chunli Shi, Jie Wang, Shubin Di, Shaobing Zhou*,pH-triggered intracellular release from actively targeting polymer Micelles,Biomaterials, 34 (2013) 4544-4554

b. anti-tumor drugs loading poly(acid-anhydride) micelle with reduction sensitivety


As shown in figure, the anti-tumor drug-curcumin was chosen as model drug, we succeeded in preparation of new poly(acid-anhydride) micelle for cancer treatment, in the effect of glutathione, nearly zero drug release profile was achieved, and in vivo experiment proved that the micelle can quick release drugs within the tumor cells, and showed obviously inhibitory effect on tumor growth (as shown)

Figure. the drug release mechanism and tumor inhibition effect in vitro and in vivo of reduction sensitive poly(acid-anhydride) micelle.
*Jie Wang, Guang Yang, Xing Guo, Zhaomin Tang, Zhendong Zhong, Shaobing Zhou*, Redox-responsive polyanhydride micelles for cancer therapy, Biomaterials, 2014, 35, 3080-3090.

2. Biomedical biodegradable shape memory polymer material and composite material research

a. Synthesis and characterization of triple shape memory polyurethane material.

A new triple shape memory polyurethane (TSMPU) with pendant cinnamon groups was synthesized via a photo crosslinking of cinnamon groups irradiated under λ > 280 nm ultraviolet light.
*Lin Wang, Xifeng Yang, Hongmei Chen, Tao Gong, Wenbing Li, Guang Yang, and Shaobing Zhou*, Design of Triple-Shape Memory Polyurethane with Photo-crosslinking of Cinnamon Groups, ACS Applied Materials & Interfaces, 2013, 5, 10520-10528.

b. Porous shape memory tissue engineering scaffolds


Biodegradable shape memory polymer material were processed spongy porous scaffolds, and then compress it to make the stents into smaller, so that it can easily be implanted bone defect site, the compressed stents in bone defect site can finely recover its shape under the body temperature, and the defect parts fill completely (as shown).

Figure. The recovery of the shape memory polymer scaffolds carrying growth factor under temperature stimulation in the shape of the bone defect.

*Xian Liu, Kun Zhao, Tao Gong, Jian Song, Chongyun Bao, En Luo, Jie Weng and Shaobing Zhou*, Delivery of Growth Factors Using a Smart Porous Nanocomposite Scaffold to Repair a Mandibular Bone Defect, Biomacromolecules, 2014,15, 1019-1030.

3. The application of electrospinning fiber in drug release and tissue engineering.

a. Magnetic tissue engineering scaffolds


Here is for magnetic responsiveness scaffolds
*Long Li, Guang Yang, Jinrong Li, Shan Ding, Shaobing Zhou*,Cell behaviors on magnetic electrospun poly-d, l-lactide nanofibers,Materials Science and Engineering C 34 (2014) 252–261.

b. Drug-loaded electrospinning for scar repair.
Aiming at skin scar a knot in the clinical refractory disease, We prepared a new type of medical dressings by carrying a two-component medicine using absorbable polymer fiber membrane, for delivering transdermal drug to repair of keloid treatments (as shown in figure).After the treatment of keloids model in nude mice experiments, it showed that drug-loaded fiber not only processed obvious antibacterial function, but also significantly soften keloids and the keloid volume change is more obviously than with traditional silicon gel sticking group

.
Figure. The illustration of percutaneous drug delivery of dual drug-loaded ne of electrospinning polymer fiber membrane.
*Jinrong Li, Rong Fu, Long Li, Guang Yang, Shan Ding, Zhendong Zhong, Shaobing Zhou*, Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid, Pharm Res, DOI 10.1007/s11095-013-1266-2.

c. a biodegradable polymer electrospinning fiber for tissue engineering scaffolds by electrical stimulation

Tissue engineering scaffolds with high porosity, high permeability can be prepared by electrospinning, and electrospun fiber can act as carrier of drug and bioactive compounds such as growth factors, at the same time the function of electrospinning fiber can be improved by blend of other organic or inorganic materials, and thus better simulation of the extracellular matrix structure and function can be obtained.

* Shijun Shao, Shaobing Zhou, Long Li, Jinrong Li, Chao Luo, Jianxin Wang, Xiaohong Li, Jie Weng.Osteoblast function on electrically conductive electrospun PLA/MWCNTs nanofibers. Biomaterials 2011,32, 2821-2833.

 

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