Yuan Tian, Ph. D.

 

School of Life Science and Engineering • Southwest Jiaotong University

ty@swjtu.edu.cn / i.tyuan@qq.com • (+86)176 0288 5568

 

EDUCATION AND ACADEMIC EXPERIENCE

 

Ph. D., School of Chemical Biology and Biotechnology, Peking University, China

Advisor: Prof. Zigang Li

Sept. 2011-July 2016


B. S., West China School of Pharmacy, Sichuan University, China

Sept. 2007-July 2011


 

HONORS AND AWARDS

 

  • WuXi AppTec Academic Scholarship & Excellent Poster Presentation Award, SCBB, Shenzhen Graduate School of Peking University, 2015
  • Shimadzu Scholarship, SCBB, Shenzhen Graduate School of Peking University, 2014
  • Merit Student, Peking University, 2014
  • PowerLeader Interdisciplinary Research Scholarship, SCBB, Shenzhen Graduate School of Peking University, 2013
  • Social Work Scholarship, Peking University, 2013
  • Outstanding Student & Student Cadre, Sichuan University, 2008-2009

 

 

RESEARCH INTEREST

 

  • Peptide therapeutics: Inventing new chemistry to stabilize and recapitulate the native conformation of protein secondary structure elements to enhance their therapeutic properties.

 

  • Drug delivery system: Stapled peptides-assisted targeted drug delivery for cancer therapy.

 

 

PUBLICATIONS

(‡ contributed equally; * corresponding author)

 

19. Ming Y., Xiao Y., Tian Y.*, Zhou S. B.*, “Cell-Membrane Penetration of Tat-Conjugated Polymeric Micelles: Effect of Tat Coating Density.” Macromol. Biosci., 2019, In Press. (co-corresponding author)

 

18. Yuan F.‡, Tian Y.‡, Qin W. R.‡, Li J. X., Yang D., Zhao B. C., Yin F.*, Li Z. G.*, “Evaluation of Topologically Distinct Constrained Antimicrobial Peptides with Broad-Spectrum Antimicrobial Activity” Org. Biomol. Chem., 2018, 16, 5764-5770. (contributed equally)

 

17. Qin. X, Zhao. H, Jiang Y. H., Yin F., Tian Y., Xie M. S., Ye X. Y., Xu N. H., Li Z. G.*, "Development of a potent peptide inhibitor of estrogen receptor α" Chin. Chem. Lett., 2018, 29, 1160-1162.

 

16. Shi, X. D., Zhao, R. T., Jiang, Y. X., Zhao, H., Tian, Y., Jiang, Y. H., Li, J. X., Qin, W. R., Yin, F.*, Li, Z. G.*,“Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation” Chem. Sci., 2018,9, 3227-3232.

 

15. Shi, X. D.‡, Jiang, Y. X.‡, Yang, D.‡, Zhao, H., Tian, Y.*, Li, Z. G.*, “Reversibly Switching the Conformation of Short Peptide through In-Tether Chiral Sulfonium Auxiliary.” Chin. Chem. Lett., 2018, 29, 485-488. (co-corresponding author)

 

14. Tian, Y.‡, Zeng, X. Z.‡, Li, J. X.‡, Jiang, Y. H., Zhao, H., Wang, D. Y., Huang, X. H.*, Li, Z. G.*, “Achieving Enhanced Cell Penetration of Short Conformationally Constrained Peptides through Amphiphilicity Tuning.” Chem. Sci., 2017, 8, 7576-7581.

 

13. Tian, Y.‡, Jiang, Y. H.‡, Li, J. X., Wang, D. Y., Zhao, H., Li, Z. G.*, “Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α-Helical Peptides: a Comparative Study.” ChemBioChem, 2017, 18, 2087-2093. (Inside Back Cover)

 

12. Li, J. X., Hu, K., Chen, H. L., Wu, Y. J., Chen, L. J., Yin, F.*, Tian, Y.*, Li, Z. G.*, “In-tether chiral center modulates the proapoptotic activity of KLA peptide.” Chem. Commun., 2017, 53, 10452-10455. (co-corresponding author)

 

11. Zhao H.‡, Qin X.‡, Yang D.‡, Jiang Y. H., Zheng W. H., Wang D. Y., Tian Y., Liu Q. S., Xu N. H.* and Li Z. G.*, “The development of activatable lytic peptides for targeting triple negative breast cancer” Cell Death Discov., 2017, 3, 17037.

 

10. Jiang, Y. H., Zhao, H., Tian, Y., Li, Z. G.*, “Lipid–Cell-Penetrating-Peptide Conjugates as Effective Delivery Systems.” Synlett, 2017, 28, 1897-1900.

 

9. Tian, Y.‡, Yang, D.‡, Ye, X. Y.*, Li, Z. G.*, “Thioether-Derived Macrocycle for Peptide Secondary Structure Fixation.” Chem. Rec., 2017, 17, 874-885.

 

8. Zhao, H., Jiang, Y. H., Tian, Y., Qin, X., Li, Z. G.*, “Improving Cell Penetration of Helical Peptides Stabilized by N-Terminal Crosslinked Aspartic Acids.” Org. Biomol. Chem., 2017, 15, 459-464.

 

7. Li, J. X., Tian, Y., Wang, D. Y., Li, Z. G.*, “An In-Tether Sulfoxide Chiral Center Influences the Biophysical Properties of the N-Capped Peptides.” Bioorg. Med. Chem., 2016, 25, 1756-1761.

6. Zhang, Q. Z., Jiang, F., Zhao, B. C., Lin, H. C., Tian, Y., Xie, M. S., Bai, G. Y., Gilbert, A. M., Gietz, G. H., Liras, S., Mathiowetz, A. A., Price, D. A., Song, K., Tu, M. H., Wu, Y. J., Wang, T.*, Flanagan. M. E.*, Wu, Y. D.*, Li, Z. G.*, “Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity.” Sci. Rep., 2016, 6, 38573.

5. Zhao, H.‡, Liu, Q. S.‡, Geng, H.‡, Tian, Y., Cheng, M., Jiang, Y. H., Xie, M. S., Niu, X. G., Jiang, F., Zhang, Y. O., Lao, Y. Z., Wu, Y. D.*, Xu., N. H.*, Li, Z. G.*, “Cross-Linked Aspartic Acids as Helix-Nucleating Templates.” Angew. Chem. Int. Ed., 2016, 128, 12088-12093.

4. Tian, Y.‡, Wang, D. Y.‡, Li, J. X., Shi, C., Zhao, H., Li, Z. G.*, “A Proline-Derived Transannular N-Cap for Nucleation of Short α-Helical Peptides.” Chem. Commun., 2016, 52, 9275-9278.

3. Tian, Y., Li, J. X., Zhao, H., Zeng, X. Z., Liu, Q. S., Wang, D. Y., Niu, X. G., Huang, X. H., Xu, N. H.*, Li, Z. G.*, “Stapling of Unprotected Helical Peptides via Photo-Induced Intramolecular Thiol-Yne Hydrothiolation.” Chem. Sci., 2016, 7, 3325-3330.

2. Liu, Q. S.‡, Zhao, H.‡, Jiang, Y. H., Wu, M., Tian, Y., Wang, D. P., Lao, Y. Z., Xu, N. H., Li, Z. G.*, “Development of a Lytic Peptide Derived from BH3-Only Proteins.” Cell Death Discov., 2016, 2, 16008.

1. Zhang, Q. Z., Tian, Y., Lao, Y. Z., Li, Z. G.*, “Peptides-Staple Method Development and Its Application in Cancer Therapy.” Curr. Med. Chem., 2014, 21, 2438-2452.