Yuan Tian, Ph. D.

 

School of Life Science and Engineering • Southwest Jiaotong University

ty@swjtu.edu.cn / i.tyuan@qq.com • (+86)176 0288 5568

 

EDUCATION AND ACADEMIC EXPERIENCE

 

Ph. D., School of Chemical Biology and Biotechnology, Peking University, China

Advisor: Prof. Zigang Li

Sept. 2011-July 2016


B. S., West China School of Pharmacy, Sichuan University, China

Sept. 2007-July 2011


 

HONORS AND AWARDS

 

  • WuXi AppTec Academic Scholarship & Excellent Poster Presentation Award, SCBB, Shenzhen Graduate School of Peking University, 2015
  • Shimadzu Scholarship, SCBB, Shenzhen Graduate School of Peking University, 2014
  • Merit Student, Peking University, 2014
  • PowerLeader Interdisciplinary Research Scholarship, SCBB, Shenzhen Graduate School of Peking University, 2013
  • Social Work Scholarship, Peking University, 2013
  • Outstanding Student & Student Cadre, Sichuan University, 2008-2009

 

 

RESEARCH INTEREST

 

  • Peptide therapeutics: Inventing new chemistry to stabilize and recapitulate the native conformation of protein secondary structure elements to enhance their therapeutic properties.

 

  • Drug delivery system: Stapled peptides-assisted targeted drug delivery for cancer therapy.

 

 

PUBLICATIONS

(‡ contributed equally; * corresponding author)

 

15. Tian, Y.‡, Zeng, X. Z.‡, Li, J. X.‡, Jiang, Y. H., Zhao, H., Wang, D. Y., Huang, X. H.*, Li, Z. G.*, “Achieving Enhanced Cell Penetration of Short Conformationally Constrained Peptides through Amphiphilicity Tuning.” Chem. Sci., 2017, Accepted.

 

14. Tian, Y.‡, Jiang, Y. H.‡, Li, J. X., Wang, D. Y., Zhao, H., Li, Z. G.*, “Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α-Helical Peptides: a Comparative Study.” ChemBioChem, 2017, Accepted.

 

13. Li, J. X., Hu, K., Chen, H. L., Wu, Y. J., Chen, L. J., Yin, F.*, Tian, Y.*, Li, Z. G.*, “In-tether chiral center modulates the proapoptotic activity of KLA peptide.” Chem. Commun., 2017, In Press. (co-corresponding author)

 

12. Shi, X. D.‡, Jiang, Y. X.‡, Yang, D.‡, Zhao, H., Tian, Y.*, Li, Z. G.*, “Reversibly Switching the Conformation of Short Peptide through In-Tether Chiral Sulfonium Auxiliary.” Chin. Chem. Lett., 2017, In Press. (co-corresponding author)

 

11. Zhao H.‡, Qin X.‡, Yang D.‡, Jiang Y. H., Zheng W. H., Wang D. Y., Tian Y., Liu Q. S., Xu N. H.* and Li Z. G.*, “The development of activatable lytic peptides for targeting triple negative breast cancer” Cell Death Discov., 2017, 3, 17037.

 

10. Jiang, Y. H., Zhao, H., Tian, Y., Li, Z. G.*, “Lipid–Cell-Penetrating-Peptide Conjugates as Effective Delivery Systems.” Synlett, 2017, 28, 1897-1900.

 

9. Tian, Y.‡, Yang, D.‡, Ye, X. Y.*, Li, Z. G.*, “Thioether-Derived Macrocycle for Peptide Secondary Structure Fixation.” Chem. Rec., 2017, 17, 874-885.

 

8. Zhao, H., Jiang, Y. H., Tian, Y., Qin, X., Li, Z. G.*, “Improving Cell Penetration of Helical Peptides Stabilized by N-Terminal Crosslinked Aspartic Acids.” Org. Biomol. Chem., 2017, 15, 459-464.

 

7. Li, J. X., Tian, Y., Wang, D. Y., Li, Z. G.*, “An In-Tether Sulfoxide Chiral Center Influences the Biophysical Properties of the N-Capped Peptides.” Bioorg. Med. Chem., 2016, 25, 1756-1761.

6. Zhang, Q. Z., Jiang, F., Zhao, B. C., Lin, H. C., Tian, Y., Xie, M. S., Bai, G. Y., Gilbert, A. M., Gietz, G. H., Liras, S., Mathiowetz, A. A., Price, D. A., Song, K., Tu, M. H., Wu, Y. J., Wang, T.*, Flanagan. M. E.*, Wu, Y. D.*, Li, Z. G.*, “Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity.” Sci. Rep., 2016, 6, 38573.

5. Zhao, H.‡, Liu, Q. S.‡, Geng, H.‡, Tian, Y., Cheng, M., Jiang, Y. H., Xie, M. S., Niu, X. G., Jiang, F., Zhang, Y. O., Lao, Y. Z., Wu, Y. D.*, Xu., N. H.*, Li, Z. G.*, “Cross-Linked Aspartic Acids as Helix-Nucleating Templates.” Angew. Chem. Int. Ed., 2016, 128, 12088-12093.

4. Tian, Y.‡, Wang, D. Y.‡, Li, J. X., Shi, C., Zhao, H., Li, Z. G.*, “A Proline-Derived Transannular N-Cap for Nucleation of Short α-Helical Peptides.” Chem. Commun., 2016, 52, 9275-9278.

3. Tian, Y., Li, J. X., Zhao, H., Zeng, X. Z., Liu, Q. S., Wang, D. Y., Niu, X. G., Huang, X. H., Xu, N. H.*, Li, Z. G.*, “Stapling of Unprotected Helical Peptides via Photo-Induced Intramolecular Thiol-Yne Hydrothiolation.” Chem. Sci., 2016, 7, 3325-3330.

2. Liu, Q. S.‡, Zhao, H.‡, Jiang, Y. H., Wu, M., Tian, Y., Wang, D. P., Lao, Y. Z., Xu, N. H., Li, Z. G.*, “Development of a Lytic Peptide Derived from BH3-Only Proteins.” Cell Death Discov., 2016, 2, 16008.

1. Zhang, Q. Z., Tian, Y., Lao, Y. Z., Li, Z. G.*, “Peptides-Staple Method Development and Its Application in Cancer Therapy.” Curr. Med. Chem., 2014, 21, 2438-2452.